Rédaction Africa Links 24 with Sade Oguntola
Published on 2024-04-03 23:35:44
Khaya grandifoliola, also known as African mahogany, has shown promise in the treatment of cerebral malaria, a severe and potentially fatal form of the disease. Traditional healers have long used this plant as an anti-malarial remedy, primarily utilizing the bark and seeds for their medicinal properties.
In a recent study, researchers investigated the effectiveness of Khaya grandifoliola stem bark ethanol extract in reducing malaria parasites in laboratory conditions. The results were promising, with the extract demonstrating a significant suppressive effect on the parasites at various doses. This study aimed to validate the traditional use of this plant in treating malaria by providing scientific evidence of its efficacy.
The researchers infected thirty mice with malaria parasites and then divided them into different treatment groups, along with a control group of non-parasitized mice. After four days of treatment with the extract, the level of malaria parasites in each group was assessed over a period of time, and the overall survival rate was calculated.
The study revealed that the chemical constituents present in Khaya grandifoliola, such as alkaloids, terpenoids, tannins, saponins, and anthraquinones, contribute to its antiplasmodial activity. The researchers explained that these compounds work synergistically to inhibit parasite growth and development, ultimately leading to a reduction in parasite levels.
Furthermore, other studies have also highlighted the potential of natural compounds like curcumin from turmeric and rocaglates from plants of the Aglaia species in treating cerebral malaria. Curcumin has shown promising results in curing cerebral malaria in experimental mice, while rocaglates have demonstrated the ability to block parasite replication and reduce neurological inflammation, potentially offering a new approach to treating complicated malaria cases.
Cerebral malaria poses a significant threat to vulnerable populations, particularly pregnant women and children, with severe neurological complications accounting for a large portion of infant mortality in some regions of Africa. While uncomplicated malaria can be treated with antimalarial drugs, the options for cerebral malaria are limited, and drug resistance poses a significant challenge.
The findings from these studies underscore the importance of exploring alternative treatment options for cerebral malaria, especially in light of emerging drug resistance. Natural compounds like those found in Khaya grandifoliola, turmeric, and rocaglates offer potential solutions that could help improve outcomes for patients with this severe form of the disease.
In conclusion, the research on Khaya grandifoliola and other natural compounds highlights the potential of traditional remedies in the treatment of cerebral malaria. By further investigating these plant-based therapies and their mechanisms of action, scientists may uncover new and effective strategies for combating this deadly disease.
Read the original article on Nigerian Tribune
